Endocrine Abstracts

Pasireotide is a second-line therapy for acromegaly, that allows to obtain disease control in patients previously uncontrolled. However, pasireotide-induced hyperglycemia is of major concern. Currently, few data concerning prolonged use of pasireotide are available. The current retrospective study aimed at investigating the efficacy and safety of long-term pasireotide therapy. Sixteen consecutive patients (5 males, 11 females, age 47 ± 11 years) undergoing pasireotide for...

Non-alcoholic fatty liver disease (NAFLD) is becoming more common over the world. Its predisposition for evolving to cirrhosis and hepatocellular cancer, as well as its link to extrahepatic symptoms, puts patients and clinicians under a double burden. Several studies have found a link between NAFLD and many endocrinopathies, demonstrating a substantial bi-directional link between NAFLD and hypogonadism, in both men and women. In man with T2DM, NAFLD is linked to reduced total ...

Introduction and Objetive: The composition of human gut microbiota is an emerging field of research and is currently regarded as pathophysiologically linked to obesity. However, we still lack a thorough understanding of what constitutes health and disease in this subject. We present herein a descriptive study of the gut microbiota composition among Spanish morbidly obese subjects, clustered regarding the carbohydrate metabolism status (CHMS) displayed.Me...

Introduction: Thyroid nodules are very common in the general population (20-75% ultrasound). There are clinical management criteria established by international societies and standardized cytological diagnostic criteria (Bethesda). However, there is still uncertainty in the management of category 5.Objectives: To evaluate the clinical attitude to the cytological diagnosis of Bethesda category 5 (B5) in thyroid fine-needle aspiration cytology (FNA). And s...

Introduction: The adult Turner Syndrome (TS) clinic at UCLH has collected data on over 800 women, attending for up to 20 years comprising over 8000 clinic visits. Data from this cohort forms the Turner Life Course Project. This large dataset allows analysis of pathogenesis of common chronic conditions including diabetes mellitus (DM) and hypothyroidism. There is some debate about the classification of DM associated with TS, with an over representation of up to 11-fold of type ...

Background: Transition from paediatric to adult services is a crucial process for young adults with long term conditions (LTC) affecting quality of life and engagement with medical services. The recent NICE report has outlined overarching principles for an effective transition. This can be a challenge for paediatricians and adult physicians as both hospital sites and medical/nursing teams can change. There is a dearth of evidence regardin...

Introduction: The adult Turner Syndrome (TS) clinic at UCLH has collected data on over 800 women, attending for up to 20 years comprising over 8000 clinic visits. Data from this cohort forms the Turner Life Course Project. This large dataset allows analysis of pathogenesis of common chronic conditions including diabetes mellitus (DM) and hypothyroidism. There is some debate about the classification of DM associated with TS, with an over representation of up to 11-fold of type ...

Background: Transition from paediatric to adult services is a crucial process for young adults with long term conditions (LTC) affecting quality of life and engagement with medical services. The recent NICE report has outlined overarching principles for an effective transition. This can be a challenge for paediatricians and adult physicians as both hospital sites and medical/nursing teams can change. There is a dearth of evidence regardin...

Despite an accurate management, in about 20% of hypothyroid patients showing an increased need for oral levothyroxine (LT4), the leading cause of treatment refractoriness remains unknown. Some studies hypothesized the relationship between gut microbiota composition and thyroid homeostasis, but the possible involvement of microflora in the efficacy of LT4 treatment has not been evaluated yet, and this represents the aim of our study. We examined the faecal microflora compositio...

Colon polyps represent a frequent complication of acromegaly. Knowledge about prevalence and risk factors of polyps’ recurrence in acromegalic patients is still limited. The current retrospective study aimed at investigating polyps’ prevalence and recurrence risk factors in acromegalic patients. One hundred and forty-three patients (73 males, 70 females) referring to “Federico II” university diagnosed with acromegaly from 2000 to 2022 who underwent at least...